Publications

 ^^Co-corresponding, *co-first authorship. DahlmanLab members & alumni bolded.

​Dahlman Lab (2016 - current)
ADVANCED HEALTHCARE MATERIALS | 2021
Dobrowolski C, Paunovska K, Hatit MZC,  Lokugamage MP, Dahlman JE

Therapeutic RNA delivery for COVID and other diseases
nature | 2021
Somatic Cell Gene Editing Principal Investigators

THE NIH Somatic Cell Gene Editing Program
nature Biotechnology | 2020
Alter G, Bingham K, Corey L, Dahlman JE, Jackson N, Moore J, Rappuoli R

Whither COVID-19 vaccines?
HUMAN GENE THERAPY | 2020
Da Silva Sanchez AJ*, Paunovska K*, Cristian A, Dahlman J​E

Treating Cystic Fibrosis with mRNA and CRISPR
SCIENCE Advances | 2020
Paunovska K*, Da Silva Sanchez AJ*, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman J​E

Increased PIP3 activity blocks nanoparticle mRNA delivery 
​Bioengineering and Translational medicine | 2020
Gan Z*, Lokugamage MP*, Hatit MZC, Loughrey D, Paunovska K, Sato M, Cristian A, Dahlman JE

Nanoparticles containing constrained phospholipids deliver mRNA to immune cells without targeting ligands
ADVANCED MATERIALS | 2019
Lokugamage MP, Gan Z, Zurla C, Levin J, Islam F, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE

Mild innate immune activation overrides efficient nanoparticle-mediated RNA delivery 
Nature metabolism | 2019
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Sharvari G, Clifone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwarts MA, Pober JS, Chittenden TW, Tellides G, Simons M
Endothelial TGF-ß signaling drives vascular inflammation and atherosclerosis
ADVANCED MATERIALS | 2019
Lokugamage MP*, Sago CD*, Gan Z, Krupczak BR, Dahlman JE
Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands
ADVANCED MATERIALS | 2019
Paunovska K*, Loughrey D, Sago CD, Langer R, Dahlman JE
 Using large datasets to understand nanotechnology​
Nucleic Acid THERAPEUTICS | 2019
Brown JM, Dahlman JE, Neuman K, Prata C, Krampert M, Hadwiger P, Vornlocher​ HP
Ligand conjugated multimeric siRNAs enable enhanced uptake and multiplexed gene silencing 
Scientific American | 2019
Dahlman JE
All the world's data could fit in an egg: How DNA is used to store - and generate - information and extreme scales. 
Cellular and Molecular ​Bioengineering​ | 2019
Sago CD, Krupczak BR, Lokugamage MP,
​Gan Z, ​Dahlman JE
Cell subtypes within the liver microenvironment differentially interact with lipid nanoparticles
CMBE 2020 Editors' Choice Award.
Circulation​ | 2019
Yu Q et al
BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension
advanced materials | 2019
Paunovska K, Da Silva Sanchez A, Sago CD, Gan Z, Lokugamage MP, Islam F, Kalathoor S, Krupczak BR, Dahlman JE
​Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses
​JACS | 2018
Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE
Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
Featured on cover. Highlighted by JACS. 
science​ | 2018
Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ
Editing nature: Local roots of global governance
​Nano Letters | 2018
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shan NN, Syed C, Bryksin AV, Dahlman JE
Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo 
​Featured on cover.
​PNAS | 2018
​Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco, CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari P, Kirschman JL, Willett N, Jang Y, Santangelo PJ, Bryksin AV,
​Dahlman JE
​A high thoughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Journal of materials chemistry b | 2018
Sago CD, Kalathoor S, Fitzgerald JP, Lando, GN, Djeddar N, Bryksin AV, Dahlman JE
​
Barcoding chemical modifications into nucleic acids improves drug stability in vivo 
​Featured on cover.
     Invited - Emerging Investigators Issues.
Current Opinion in Biomedical ​Enginee​ring | 2018 
Lokugamage MP, Sago CD, Dahlman JE
Testing thousands of nanoparticles in vivo using DNA barcodes
​ACS Nano​ | 2018
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE
​Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery
​Nano Letters | 2018
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE
A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation
     Covered by Nature Biotech, Journal of Controlled Release, GenEng news, and others.
​Journal of the American Heart Association | 2018
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA
​ Inhibiting integrin alpha 5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis
PNAS | 2017
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
​Covered by MIT, Florida, GaTech, and many other news organizations.
Ph.D. (Robert Langer, MIT) and post-doc (Feng Zhang, Broad)
​Nature Cell Biology​
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. 
INTERACTION BETWEEN INTEGRIN ALPHA5 AND PDE4D REGULATES ENDOTHELIAL INFLAMMATORY SIGNALLING
​Circulation Research​
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE,  Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. 
PROLIFERATION AND RECRUITMENT CONTRIBUTE TO MYOCARDIAL MACROPHAGE EXPANSION IN CHRONIC HEART FAILURE
​Science Translational Medicine
Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M
NANOPARTICLE-ENABLED RNAi IN ENDOTHELIAL CELLS REDUCES VASCULAR INFLAMMATION AFTER MYOCARDIAL INFARCTION
Featured on cover.
     Cover image awarded top 10 scientific images of the year by NSF. Covered by MGH news, Nature Reviews Cardiology, and Science. ​
JACS
Tibbitt MW, Dahlman JE, Langer R.
EMERGING FRONTIERS IN DRUG DELIVERY​
​Nature Biotechnology​ 
Dahlman JE^^, Abudayyeh OA*, Joung J, Gootenberg JS, Zhang F, Konermann S
ORTHOGONAL GENE KNOCK OUT AND ACTIVATION WITH A CATALYTICALLY ACTIVE CAS9 NUCLEASE
​Wires Nanomedicine and Nanobiotechnology​
Stewart MP, Lorenz A, Dahlman JE, Sahay G
CHALLENGES IN CARRIER MEDIATED INTRACELLULAR DELIVERY: MOVING BEYOND ENDOSOMAL BARRIERS
​Atherosclerosis, Thrombosis, and Vascular Biology
Koga J*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M
MACROPHAGE NOTCH LIGAND DELTA-LIKE 4 PROMOTES THE LESION DEVELOPMENT OF VEIN GRAFTS: IMPLICATIONS FOR THE TREATMENT OF VEIN GRAFT FAILURE 
​​Featured on cover.
     Awarded best ATVB cover of 2015.
Nano Letters​ 
Khan OF, Zaia E, Jhunjhunwala S, Xue W, Wenxin C, Dong YS, Barnes C, Dahlman JE, Dong Y, Pelet J, Webber M, Tsosie J, Jacks T, Langer R, Anderson DG
DENDRIMER-INSPIRED NANOMATERIALS FOR THE IN VIVO DELIVERY OF siRNA TO LUNG VASCULATURE
EMBO Molecular Medicine
White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BR, Kumar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY
GENETIC AND HYPOXIC ALTERATIONS OF THE MIR-210-ISCU1/2 AXIS PROMOTE IRON-SULFATE DEFICIENCY AND PULMONARY HYPERTENSION​
​Scientific Reports​ 
Herr KJ, Tsang YN, En JO, Qiushi L, Yap LL Yu W, Yin H, Bogorad R, ​Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, ​Kotelianky V, Viasnoff V 
ALPHA-CATENIN ELICITS A CHOLESTATIC RESPONSE AND IMPAIRS LIVER REGENERATION​
​​Angewandte Chemie
Khan OF, Zaia E, Yin H, Bororad R, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG
CHEMICALLY MODIFIED DENDRIMERS WITH ALKYL CHAIN-SUBSTITUTED AMINES FOR siRNA DELIVERY TO THE LIVER ENDOTHELIUM IN VIVO
​Advances in Genetics
Dahlman JE, Kauffman K, Langer R, Anderson DG ​
​NANOTECHNOLOGY FOR IN VIVO TARGETED SIRNA DELIVERY
Cell
Platt RJ, Chen S, Zhou Y, Yim M, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovico M, Jhunjhunwala S, Graham DB, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Zhang F
CRISPR-CAS9 KNOCKIN MICE FOR GENOME EDITING AND CANCER MODELING​
 Featured on cover.
​     Covered by Broad, MIT, and others. 
​PNAS​
Xue W*, Dahlman JE*, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T
SMALL RNA COMBINATION THERAPY FOR LUNG CANCER
Covered by MIT News ​
​Nature Nanotechnology​
Dahlman JE