Publications

 ^^Co-corresponding, *co-first authorship. DahlmanLab members & alumni bolded.

​Dahlman Lab (2016 - current)
Nature nanotechnology | 2022
Dobrowolski CN*, Paunovska K*, Echeverri ES, Ni H, Hatit MCZ, Loughrey D, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE​

Nanoparticle single-cell multiomic readouts
reveal that cell heterogeneity influences lipid
nanoparticle-mediated messenger RNA delivery​
Nature chemistry | 2022
Hatit MZC*, Dobrowolski CN*, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Paunovska K, Peck HE, Kim JJ, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE

Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
Nano letters | 2022
Da Silva Sanchez AJ, Dobrowolski CN, Cristian A, Schrader Echeverri E, Zhao K,
Hatit MZC, Loughrey D, Paunovska K*, and Dahlman JE*

Universal barcoding predicts in vivo ApoE-independent lipid
nanoparticle delivery
Nature COMMUNICATIONS | 2022
Ni H*, Hatit MZC*, Zhao K*, Loughrey D, Lokugamage MP, Peck HE, Del Cid A, Muralidharan A, YongTae Kim Y, Santangelo PJ, Dahlman JE

Piperazine-derived lipid nanoparticles
deliver mRNA to immune cells
in vivo
Nature BIOMEDICAL ENGINEERING | 2022
Sago CD*, Lokugamage MP*,  Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Schrader E, Fitzgerald JP, Gan Z, Gamboa L, Castro MG, Paunovska K, Sanhueza CA, Finn MG, Santangelo PJ, Dahlman JE

Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
Nature Nanotechnology | 2022
Hatit MZC*, Lokugamage MP*, Dobrowolski CN*, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE

Species-dependent in vivo mRNA delivery and cellular response to nanoparticles
Nature Reviews Genetics | 2022
Paunovska K, Loughrey D, Dahlman JE 

Drug delivery systems for RNA therapeutics
(cover feature)​
Data in Brief | 2021
Miracle D, Dahlman A, Wilks G,
​Dahlman JE

Dataset of bond enthalpies (εAA, εAB, εBB) in 975 binary intermetallic compounds
Accounts of Chemical Research | 2021
Loughrey D, Dahlman JE​

Non-liver mRNA delivery

Published as part of the ACR special issue “mRNA Therapeutics” 
Nature Biomedical Engineering | ​2021
Lokugamage MP*, Vanover D*, Beyersdorf J*, Hatit MZC*, Rotolo L, Peck HE, Schrader E, Ni H, Yoon JK, Kim Y, Santangelo PJ, Dahlman JE

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
 Journal of Clinical Investigation | 2021
Culley MK ​et al.

Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
nATURE bIOTECHNOLOGY | 2021
Annabi N ​et al.

Voices of biotech research

25th anniversary issue
ADVANCED HEALTHCARE MATERIALS | 2021
Dobrowolski C, Paunovska K, Hatit MZC, Lokugamage MP, Dahlman JE

Therapeutic RNA delivery for COVID and other diseases
nature | 2021
Somatic Cell Genome Editing Consortium

The NIH Somatic Cell Genome Editing program
nature Biotechnology | 2020
Alter G, Bingham K, Corey L, Dahlman JE, Jackson N, Moore J, Rappuoli R

Whither COVID-19 vaccines?
HUMAN GENE THERAPY | 2020
Da Silva Sanchez AJ*, Paunovska K*, Cristian A, Dahlman J​E

Treating cystic fibrosis with mRNA and CRISPR
SCIENCE Advances | 2020
Paunovska K*, Da Silva Sanchez AJ*, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman J​E

Increased PIP3 activity blocks nanoparticle mRNA delivery 
​Bioengineering and Translational medicine | 2020
Gan Z*, Lokugamage MP*, Hatit MZC, Loughrey D, Paunovska K, Sato M, Cristian A, Dahlman JE

Nanoparticles containing constrained phospholipids deliver mRNA to immune cells without targeting ligands
ADVANCED MATERIALS | 2019
Lokugamage MP, Gan Z, Zurla C, Levin J, Islam F, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE

Mild innate immune activation overrides efficient nanoparticle-mediated RNA delivery 
Nature metabolism | 2019
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Sharvari G, Clifone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwarts MA, Pober JS, Chittenden TW, Tellides G, Simons M
Endothelial TGF-ß signaling drives vascular inflammation and atherosclerosis
ADVANCED MATERIALS | 2019
Lokugamage MP*, Sago CD*, Gan Z, Krupczak BR, Dahlman JE
Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands
ADVANCED MATERIALS | 2019
Paunovska K*, Loughrey D, Sago CD, Langer R, Dahlman JE
 Using large datasets to understand nanotechnology​
Nucleic Acid THERAPEUTICS | 2019
Brown JM, Dahlman JE, Neuman K, Prata C, Krampert M, Hadwiger P, Vornlocher​ H
Ligand conjugated multimeric siRNAs enable enhanced uptake and multiplexed gene silencing 
Scientific American | 2019
Dahlman JE
All the world's data could fit in an egg: How DNA is used to store - and generate - information and extreme scales 
Cellular and Molecular ​Bioengineering​ | 2019
Sago CD, Krupczak BR, Lokugamage MP,
​Gan Z, ​Dahlman JE
Cell subtypes within the liver microenvironment differentially interact with lipid nanoparticles
CMBE 2020 Editors' Choice Award.
Circulation​ | 2019
Yu Q et al
BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension
advanced materials | 2019
Paunovska K, Da Silva Sanchez A, Sago CD, Gan Z, Lokugamage MP, Islam FZ, Kalathoor S, Krupczak BR, Dahlman JE
​Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses
​JACS | 2018
Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE
Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
Featured on cover. Highlighted by JACS. 
science​ | 2018
Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ
Editing nature: Local roots of global governance
​Nano Letters | 2018
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shah NN, Syed C, Bryksin AV, Dahlman JE
Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo 
​Featured on cover.
​PNAS | 2018
​Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari PM, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV,
​Dahlman JE
​High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Journal of materials chemistry b | 2018
Sago CD, Kalathoor S, Fitzgerald JP, Lando GN, Djeddar N, Bryksin AV, Dahlman JE
​
Barcoding chemical modifications into nucleic acids improves drug stability in vivo 
​Featured on cover.
     Invited - Emerging Investigators Issues.
Current Opinion in Biomedical ​Enginee​ring | 2018 
Lokugamage MP, Sago CD, Dahlman JE
Testing thousands of nanoparticles in vivo using DNA barcodes
​ACS Nano​ | 2018
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE
​Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery
​Nano Letters | 2018
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE
A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation
     Covered by Nature Biotech, Journal of Controlled Release, GenEng news, and others.
​Journal of the American Heart Association | 2018
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA
​ Inhibiting integrin alpha 5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis
PNAS | 2017
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
​Covered by MIT, Florida, GaTech, and many other news organizations.
Ph.D. (Robert Langer, MIT) and post-doc (Feng Zhang, Broad)
​Nature Cell Biology​
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. 
Interaction between integrin alpha5 and PDE4D regulates endothelial inflammatory signaling
​Circulation Research​
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE,  Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. 
Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
​Science Translational Medicine
Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M