Publications
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^^Co-corresponding, *co-first authorship. DahlmanLab members bolded.
Dahlman Lab (2016 - current)
Dahlman Lab (2016 - current)
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Scientific American
Dahlman JE. |
All the World’s Data Could Fit in an Egg: How DNA is Used to Store- and Generate - Information at Extreme Scales.
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Cellular and Molecular Bioengineering
Sago CD, Krupczak BR, Lokugamage MP, Gan Z, Dahlman JE. |
Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles
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Circulation
Yu Q et al. |
BOLA3 Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension
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Advanced Materials
Paunovska K, Da Silva Sanchez A, Sago CD, Gan Z, Lokugamage MP, Islam F, Kalathoor S, Krupczak BR, Dahlman JE. |
Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses
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JACS
Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE. |
Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
Featured on cover. Highlighted by JACS.
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science
Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ. |
Editing nature: Local roots of global governance
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Nano Letters
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shan NN, Syed C, Bryksin AV, Dahlman JE. |
Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo
Featured on cover.
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PNAS
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco, CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari P, Kirschman JL, Willett N, Jang Y, Santangelo PJ, Bryksin AV, Dahlman JE. |
A high throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing |
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Journal of Materials Chemistry B
Sago CD, Kalathoor S, Fitzgerald JP, Lando, GN, Djeddar N, Bryksin AV, Dahlman JE. |
Barcoding chemical modifications into nucleic acids improves drug stability in vivo
Featured on cover.
Invited - Emerging Investigators Issues. |
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Current Opinion in Biomedical Engineering
Lokugamage MP, Sago CD, Dahlman JE. |
Testing thousands of nanoparticles in vivo using DNA barcodes
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ACS Nano
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE. |
Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery
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Nano Letters
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. |
A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation
Covered by Nature Biotech, Journal of Controlled Release, GenEng news, and many other organizations.
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Journal of the American Heart Association
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA. |
Inhibiting integrin alpha5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis
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PNAS
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET. |
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Covered by MIT, Florida, GaTech, and many other news organizations.
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Ph.D. (2009 - 2014, Langer, MIT) and post-doc (2015-2016, Zhang, Broad)
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Nature Cell Biology
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. |
Interaction between integrin alpha5 and PDE4D regulates endothelial inflammatory signalling
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Circulation Research
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. |
Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
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Science Translational Medicine
Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M. |
Nanoparticle-enabled RNAi in endothelial cells reduces vascular inflammation after myocardial infarction
Featured on cover.
Cover image awarded top 10 scientific images of the year by NSF. Covered by MGH news, Nature Reviews Cardiology, and Science. |
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JACS
Tibbitt MW, Dahlman JE, Langer R. |
Emerging frontiers in drug delivery
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Nature Biotechnology
Dahlman JE^^, Abudayyeh OA*, Joung J, Gootenberg JS, Zhang F, Konermann S. |
Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease
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Wires Nanomedicine and Nanobiotechnology
Stewart MP, Lorenz A, Dahlman JE, and Sahay G. |
Challenges in carrier mediated intracellular delivery: moving beyond endosomal barriers
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Atherosclerosis, Thrombosis, and Vascular Biology
Koga J*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. |
Macrophage Notch ligand Delta-like 4 promotes the lesion development of vein grafts: implications for the treatment of vein graft failure
Featured on cover.
Awarded best ATVB cover of 2015. |
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Nano Letters
Khan OF, Zaia E, Jhunjhunwala S, Xue W, Wenxin C, Dong YS, Barnes C, Dahlman JE, Dong Y, Pelet J, Webber M, Tsosie J, Jacks T, Langer R, Anderson DG. |
Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature
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EMBO Molecular Medicine
White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BR, Kumar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. |
Genetic and hypoxic alterations of the miR-210-ISCU1/2 axis promote iron-sulfate deficiency and pulmonary hypertension
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Scientific Reports
Herr KJ, Tsang YN, En JO, Qiushi L, Yap LL Yu W, Yin H, Bogorad R, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Kotelianky V, Viasnoff V. |
Alpha-catenin elicits a cholestatic response and impairs liver regeneration
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Angewandte Chemie
Khan OF, Zaia E, Yin H, Bororad R, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG. |
Chemically modified dendrimers with alkyl chain-substituted amines for siRNA delivery to the liver endothelium in vivo
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Advances in Genetics
Dahlman JE, Kauffman K, Langer R, Anderson DG. |
Nanotechnology for in vivo targeted siRNA Delivery
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Cell
Platt RJ, Chen S, Zhou Y, Yim M, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovico M, Jhunjhunwala S, Graham DB, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Zhang F. |
CRISPR-Cas9 knockin mice for genome editing and cancer modeling
Featured on cover.
Covered by Broad, MIT, and many other organizations. |
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PNAS
Xue W*, Dahlman JE*, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. |
Small RNA combination therapy for lung cancer
Covered by MIT News.
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Nature Nanotechnology
Dahlman JE |
A lesson in communication
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Nature Nanotechnology
Dahlman JE*, Barnes C* et al. |
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Featured on cover. Highlighted in Nature Materials, MIT News, MIT Technology Review.
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Nanotechnology for the delivery of therapeutic nucleic acids
Dahlman JE, Langer R, Goldberg M. |
Lipid-like delivery materials for efficient siRNA delivery
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Nature Reviews Cancer
Schroeder A*, Heller DA*, Winslow MM*, Dahlman JE*, Pratt GW, Langer R, Jacks T, Anderson DG. |
Treating metastatic cancer with nanotechnology
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Journal of Controlled Release
Schroeder A*, Dahlman JE*, Sahay G, Love KT, Jiang S, Eltouhky AA, Levins CG, Wang Y, Anderson DG. |
Alkane-modified short polyethyleneimine for siRNA delivery
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Annual Reviews of Chemical and Biomolecular Engineering
Whitehead K, Dahlman JE, Langer R, Anderson DG. |
Silencing or stimulation? siRNA delivery and the immune system
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Acta Materialia
Miracle DB, Wilks G, Dahlman A, Dahlman JE. |
The strength of chemical bonds in solids and liquids
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Material Transactions
Dahlman J, Senkov ON, Scott JM, Miracle DB. |
Corrosion Properties of Ca based bulk metallic glasses.
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