Publications

HUMAN GENE THERAPY | 2020

Da Silva Sanchez AJ*, Paunovska K*, Cristian A, Dahlman JE

TREATING CYSTIC FIBROSIS WITH mRNA AND CRISPR

SCIENCE Advances | 2020

Paunovska K*, Da Silva Sanchez AJ*, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman JE

INCREASED PIP3 ACTIVITY BLOCKS NANOPARTICLE mRNA DELIVERY

Bioengineering and Translational medicine | 2020

Gan Z*, Lokugamage MP*, Hatit MCZ, Loughrey D, Paunovska K, Sato M, Cristian A, Dahlman JE

NANOPARTICLES CONTAINING CONSTRAINED PHOSPHOLIPIDS DELIVER mRNA TO IMMUNE CELLS IN VIVO WITHOUT TARGETING LIGANDS

ADVANCED MATERIALS | 2019

Lokugamage MP, Gan Z, Zurla C, Levin J, Islam F, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE

MILD INNATE IMMUNE ACTIVATION OVERRIDES EFFICIENT NANOPARTICLE-MEDIATED RNA DELIVERY

Nature metabolism | 2019

Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Sharvari G, Clifone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwarts MA, Pober JS, Chittenden TW, Tellides G, Simons M

ENDOTHELIAL TGF-Β SIGNALLING DRIVES VASCULAR INFLAMMATION AND ATHEROSCLEROSIS

ADVANCED MATERIALS | 2019

Lokugamage MP*, Sago CD*, Gan Z, Krupczak BR, Dahlman JE

CONSTRAINED NANOPARTICLES DELIVER siRNA AND sgRNA TO T-CELLS IN VIVO WITHOUT TARGETING LIGANDS

ADVANCED MATERIALS | 2019

Paunovska K*, Loughrey D, Sago CD, Langer R, Dahlman JE

USING LARGE DATASETS TO UNDERSTAND NANOTECHNOLOGY

Nucleic Acid THERAPEUTICS | 2019

Brown JM, Dahlman JE, Neuman K, Prata C, Krampert M, Hadwiger P, Vornlocher HP

LIGAND CONJUGATED MULTIMERIC siRNAS ENABLE ENHANCED UPTAKE AND MULTIPLEXED GENE SILENCING

Scientific American | 2019

Dahlman JE

ALL THE WORLD’S DATA COULD FIT IN AN EGG: HOW DNA IS USED TO STORE- AND GENERATE - INFORMATION AT EXTREME SCALES

Cellular and Molecular Bioengineering | 2019

Sago CD, Krupczak BR, Lokugamage MP,
Gan Z, Dahlman JE

CELL SUBTYPES WITHIN THE LIVER MICROENVIRONMENT DIFFERENTIALLY INTERACT WITH LIPID NANOPARTICLES

CMBE 2020 Editors' Choice Award.

Circulation | 2019

Yu Q et al

BOLA3 DEFICIENCY CONTROLS ENDOTHELIAL METABOLISM AND GLYCINE HOMEOSTASIS IN PULMONARY HYPERTENSION

advanced materials | 2019

Paunovska K, Da Silva Sanchez A, Sago CD, Gan Z, Lokugamage MP, Islam F, Kalathoor S, Krupczak BR, Dahlman JE

NANOPARTICLES CONTAINING OXIDIZED CHOLESTEROL DELIVER mRNA TO THE LIVER MICROENVIRONMENT AT CLINICALLY RELEVANT DOSES

JACS | 2018

Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE

NANOPARTICLES THAT DELIVER RNA TO BONE MARROW IDENTIFIED BY IN VIVO DIRECTED EVOLUTION

Featured on cover. Highlighted by JACS.

science | 2018

Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ

EDITING NATURE: LOCAL ROOTS OF GLOBAL GOVERNANCE

Nano Letters | 2018

Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shan NN, Syed C, Bryksin AV, Dahlman JE

MODIFYING A COMMONLY EXPRESSED ENDOCYTIC RECEPTOR RETARGETS NANOPARTICLES IN VIVO

Featured on cover.

PNAS | 2018

Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco, CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari P, Kirschman JL, Willett N, Jang Y, Santangelo PJ, Bryksin AV,
Dahlman JE

A HIGH THROUGHPUT IN VIVO SCREEN OF FUNCTIONAL mRNA DELIVERY IDENTIFIES NANOPARTICLES FOR ENDOTHELIAL CELL GENE EDITING

Journal of materials chemistry b | 2018

Sago CD, Kalathoor S, Fitzgerald JP, Lando, GN, Djeddar N, Bryksin AV, Dahlman JE

BARCODING CHEMICAL MODIFICATIONS INTO NUCLEIC ACIDS IMPROVES DRUG STABILITY IN VIVO

Featured on cover.
Invited - Emerging Investigators Issues.

Current Opinion in Biomedical Engineering | 2018

Lokugamage MP, Sago CD, Dahlman JE

TESTING THOUSANDS OF NANOPARTICLES IN VIVO USING DNA BARCODES

ACS Nano | 2018

Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE

ANALYZING 2,000 IN VIVO DRUG DELIVERY DATA POINTS REVEALS CHOLESTEROL STRUCTURE IMPACTS NANOPARTICLE DELIVERY

Nano Letters | 2018

Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE

A DIRECT COMPARISON OF IN VITRO AND IN VIVO NUCLEIC ACID DELIVERY MEDIATED BY HUNDREDS OF NANOPARTICLES REVEALS A WEAK CORRELATION

Covered by Nature Biotech, Journal of Controlled Release, GenEng news, and others.

Journal of the American Heart Association | 2018

Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA

INHIBITING INTEGRIN ALPHA5 CYTOPLASMIC DOMAIN SIGNALING REDUCES ATHEROSCLEROSIS AND PROMOTES ARTERIOGENESIS

PNAS | 2017

Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET

BARCODED NANOPARTICLES FOR HIGH THROUGHPUT IN VIVO DISCOVERY OF TARGETED THERAPEUTICS

Covered by MIT, Florida, GaTech, and many other news organizations.

Ph.D. (2009 - 2014, Langer, MIT) and post-doc (2015-2016, Zhang, Broad)

Nature Cell Biology

Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M.

INTERACTION BETWEEN INTEGRIN ALPHA5 AND PDE4D REGULATES ENDOTHELIAL INFLAMMATORY SIGNALLING

Circulation Research

Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M.

PROLIFERATION AND RECRUITMENT CONTRIBUTE TO MYOCARDIAL MACROPHAGE EXPANSION IN CHRONIC HEART FAILURE

Science Translational Medicine

Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M

NANOPARTICLE-ENABLED RNAi IN ENDOTHELIAL CELLS REDUCES VASCULAR INFLAMMATION AFTER MYOCARDIAL INFARCTION

Featured on cover.
Cover image awarded top 10 scientific images of the year by NSF. Covered by MGH news, Nature Reviews Cardiology, and Science.

JACS

Tibbitt MW, Dahlman JE, Langer R.

EMERGING FRONTIERS IN DRUG DELIVERY

Nature Biotechnology

Dahlman JE^^, Abudayyeh OA*, Joung J, Gootenberg JS, Zhang F, Konermann S

ORTHOGONAL GENE KNOCK OUT AND ACTIVATION WITH A CATALYTICALLY ACTIVE CAS9 NUCLEASE

Wires Nanomedicine and Nanobiotechnology

Stewart MP, Lorenz A, Dahlman JE, Sahay G

CHALLENGES IN CARRIER MEDIATED INTRACELLULAR DELIVERY: MOVING BEYOND ENDOSOMAL BARRIERS

Atherosclerosis, Thrombosis, and Vascular Biology

Koga J*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M

MACROPHAGE NOTCH LIGAND DELTA-LIKE 4 PROMOTES THE LESION DEVELOPMENT OF VEIN GRAFTS: IMPLICATIONS FOR THE TREATMENT OF VEIN GRAFT FAILURE

Featured on cover.
Awarded best ATVB cover of 2015.

Nano Letters

Khan OF, Zaia E, Jhunjhunwala S, Xue W, Wenxin C, Dong YS, Barnes C, Dahlman JE, Dong Y, Pelet J, Webber M, Tsosie J, Jacks T, Langer R, Anderson DG

DENDRIMER-INSPIRED NANOMATERIALS FOR THE IN VIVO DELIVERY OF siRNA TO LUNG VASCULATURE

EMBO Molecular Medicine

White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BR, Kumar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY

GENETIC AND HYPOXIC ALTERATIONS OF THE MIR-210-ISCU1/2 AXIS PROMOTE IRON-SULFATE DEFICIENCY AND PULMONARY HYPERTENSION

Scientific Reports

Herr KJ, Tsang YN, En JO, Qiushi L, Yap LL Yu W, Yin H, Bogorad R, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Kotelianky V, Viasnoff V

ALPHA-CATENIN ELICITS A CHOLESTATIC RESPONSE AND IMPAIRS LIVER REGENERATION

Angewandte Chemie

Khan OF, Zaia E, Yin H, Bororad R, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG

CHEMICALLY MODIFIED DENDRIMERS WITH ALKYL CHAIN-SUBSTITUTED AMINES FOR siRNA DELIVERY TO THE LIVER ENDOTHELIUM IN VIVO

Advances in Genetics

Dahlman JE, Kauffman K, Langer R, Anderson DG

NANOTECHNOLOGY FOR IN VIVO TARGETED SIRNA DELIVERY

Cell

Platt RJ, Chen S, Zhou Y, Yim M, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovico M, Jhunjhunwala S, Graham DB, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Zhang F

CRISPR-CAS9 KNOCKIN MICE FOR GENOME EDITING AND CANCER MODELING

Featured on cover.
Covered by Broad, MIT, and others.

PNAS

Xue W*, Dahlman JE*, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T

SMALL RNA COMBINATION THERAPY FOR LUNG CANCER

Covered by MIT News

Nature Nanotechnology

Dahlman JE

A LESSON IN COMMUNICATION