^^Co-corresponding, *co-first authorship. DahlmanLab members & alumni bolded.
Dahlman Lab (2016 - current)
Dahlman Lab (2016 - current)
Nature nanotechnology | 2022
Dobrowolski CN*, Paunovska K*, Echeverri ES, Ni H, Hatit MCZ, Loughrey D, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE Nanoparticle single-cell multiomic readouts
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Nature chemistry | 2022
Hatit MZC*, Dobrowolski CN*, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Paunovska K, Peck HE, Kim JJ, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery |
Nano letters | 2022
Da Silva Sanchez AJ, Dobrowolski CN, Cristian A, Schrader Echeverri E, Zhao K, Hatit MZC, Loughrey D, Paunovska K*, and Dahlman JE* Universal barcoding predicts in vivo ApoE-independent lipid
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Nature COMMUNICATIONS | 2022
Ni H*, Hatit MZC*, Zhao K*, Loughrey D, Lokugamage MP, Peck HE, Del Cid A, Muralidharan A, YongTae Kim Y, Santangelo PJ, Dahlman JE Piperazine-derived lipid nanoparticles
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Nature BIOMEDICAL ENGINEERING | 2022
Sago CD*, Lokugamage MP*, Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Schrader E, Fitzgerald JP, Gan Z, Gamboa L, Castro MG, Paunovska K, Sanhueza CA, Finn MG, Santangelo PJ, Dahlman JE Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver |
Nature Nanotechnology | 2022
Hatit MZC*, Lokugamage MP*, Dobrowolski CN*, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE Species-dependent in vivo mRNA delivery and cellular response to nanoparticles |
Nature Reviews Genetics | 2022
Paunovska K, Loughrey D, Dahlman JE Drug delivery systems for RNA therapeutics
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Data in Brief | 2021
Miracle D, Dahlman A, Wilks G, Dahlman JE Dataset of bond enthalpies (εAA, εAB, εBB) in 975 binary intermetallic compounds |
Accounts of Chemical Research | 2021
Loughrey D, Dahlman JE Non-liver mRNA deliveryPublished as part of the ACR special issue “mRNA Therapeutics”
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Nature Biomedical Engineering | 2021
Lokugamage MP*, Vanover D*, Beyersdorf J*, Hatit MZC*, Rotolo L, Peck HE, Schrader E, Ni H, Yoon JK, Kim Y, Santangelo PJ, Dahlman JE Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs |
Journal of Clinical Investigation | 2021
Culley MK et al. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension |
nATURE bIOTECHNOLOGY | 2021
Annabi N et al. Voices of biotech research25th anniversary issue
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ADVANCED HEALTHCARE MATERIALS | 2021
Dobrowolski C, Paunovska K, Hatit MZC, Lokugamage MP, Dahlman JE Therapeutic RNA delivery for COVID and other diseases |
nature | 2021
Somatic Cell Genome Editing Consortium The NIH Somatic Cell Genome Editing program |
nature Biotechnology | 2020
Alter G, Bingham K, Corey L, Dahlman JE, Jackson N, Moore J, Rappuoli R Whither COVID-19 vaccines? |
HUMAN GENE THERAPY | 2020
Da Silva Sanchez AJ*, Paunovska K*, Cristian A, Dahlman JE Treating cystic fibrosis with mRNA and CRISPR |
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Bioengineering and Translational medicine | 2020
Gan Z*, Lokugamage MP*, Hatit MZC, Loughrey D, Paunovska K, Sato M, Cristian A, Dahlman JE Nanoparticles containing constrained phospholipids deliver mRNA to immune cells without targeting ligands |
ADVANCED MATERIALS | 2019
Lokugamage MP, Gan Z, Zurla C, Levin J, Islam F, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE Mild innate immune activation overrides efficient nanoparticle-mediated RNA delivery |
Nature metabolism | 2019
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Sharvari G, Clifone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwarts MA, Pober JS, Chittenden TW, Tellides G, Simons M Endothelial TGF-ß signaling drives vascular inflammation and atherosclerosis
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ADVANCED MATERIALS | 2019
Lokugamage MP*, Sago CD*, Gan Z, Krupczak BR, Dahlman JE Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands
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ADVANCED MATERIALS | 2019
Paunovska K*, Loughrey D, Sago CD, Langer R, Dahlman JE Using large datasets to understand nanotechnology
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Nucleic Acid THERAPEUTICS | 2019
Brown JM, Dahlman JE, Neuman K, Prata C, Krampert M, Hadwiger P, Vornlocher H Ligand conjugated multimeric siRNAs enable enhanced uptake and multiplexed gene silencing
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Scientific American | 2019
Dahlman JE All the world's data could fit in an egg: How DNA is used to store - and generate - information and extreme scales
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Cellular and Molecular Bioengineering | 2019
Sago CD, Krupczak BR, Lokugamage MP, Gan Z, Dahlman JE Cell subtypes within the liver microenvironment differentially interact with lipid nanoparticles
CMBE 2020 Editors' Choice Award.
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Circulation | 2019
Yu Q et al BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension
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advanced materials | 2019
Paunovska K, Da Silva Sanchez A, Sago CD, Gan Z, Lokugamage MP, Islam FZ, Kalathoor S, Krupczak BR, Dahlman JE Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses
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JACS | 2018
Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
Featured on cover. Highlighted by JACS.
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science | 2018
Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ Editing nature: Local roots of global governance
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Nano Letters | 2018
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shah NN, Syed C, Bryksin AV, Dahlman JE Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo
Featured on cover.
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PNAS | 2018
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari PM, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
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Journal of materials chemistry b | 2018
Sago CD, Kalathoor S, Fitzgerald JP, Lando GN, Djeddar N, Bryksin AV, Dahlman JE Barcoding chemical modifications into nucleic acids improves drug stability in vivo
Featured on cover.
Invited - Emerging Investigators Issues. |
Current Opinion in Biomedical Engineering | 2018
Lokugamage MP, Sago CD, Dahlman JE Testing thousands of nanoparticles in vivo using DNA barcodes
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ACS Nano | 2018
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery
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Nano Letters | 2018
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation
Covered by Nature Biotech, Journal of Controlled Release, GenEng news, and others.
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Journal of the American Heart Association | 2018
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA Inhibiting integrin alpha 5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis
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PNAS | 2017
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Covered by MIT, Florida, GaTech, and many other news organizations.
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Ph.D. (Robert Langer, MIT) and post-doc (Feng Zhang, Broad)
Nature Cell Biology
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. Interaction between integrin alpha5 and PDE4D regulates endothelial inflammatory signaling
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Circulation Research
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
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