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^^Denotes co-corresponding authorship, *Denotes co-first authorship, Bold denotes DahlmanLab.
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shan NN, Syed C, Bryksin AV, Dahlman JE. Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo. Nano Letters, 2018.
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco, CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari P, Kirschman JL, Willett N, Jang Y, Santangelo PJ, Bryksin AV, Dahlman JE. A high throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. PNAS, 2018 (accepted).
Sago CD, Kalathoor S, Fitzgerald JP, Lando, GN, Djeddar N, Bryksin AV, Dahlman JE. Barcoding chemical modifications into nucleic acids improves drug stability in vivo. Journal of Materials Chemistry B, 2018. Invited - Emerging Investigators Issues.
Lokugamage MP, Sago CD, Dahlman JE. Testing thousands of nanoparticles in vivo using DNA barcodes. Current Opinion in Biomedical Engineering, 2018.
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE. Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery. ACS Nano, 2018.
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation. Nano Letters, 2018.
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA. Inhibiting integrin alpha5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis. Journal of the American Heart Association, 2018.
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET. Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. PNAS 2017.
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. Interaction between integrin alpha5 and PDE4D regulates endothelial inflammatory signalling. Nature Cell Biology, 2016.
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure. Circulation Research, 2016.
Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Nanoparticle-enabled RNAi in endothelial cells reduces vascular inflammation after myocardial infarction. Science Translational Medicine, 2016. Featured on cover, covered by MGH news, and covered by Science.
Tibbitt MW, Dahlman JE, Langer R. Emerging frontiers in drug delivery. Journal of the American Chemical Society, 2016.
Dahlman JE^^, Abudayyeh OA*, Joung J, Gootenberg JS, Zhang F, Konermann S. Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease. Nature Biotechnology, 2015.
Stewart MP, Lorenz A, Dahlman JE, and Sahay G. Challenges in carrier mediated intracellular delivery: moving beyond endosomal barriers. WIRES Nanomedicine and Nanobiotechnology, 2015.
Koga J*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch ligand Delta-like 4 promotes the lesion development of vein grafts: implications for the treatment of vein graft failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 2015, 35: 2343-2353. Awarded best ATVB cover, 2015.
Khan OF, Zaia E, Jhunjhunwala S, Xue W, Wenxin C, Dong YS, Barnes C, Dahlman JE, Dong Y, Pelet J, Webber M, Tsosie J, Jacks T, Langer R, Anderson DG. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Letters 2015.
White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BR, Kumar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the miR-210-ISCU1/2 axis promote iron-sulfate deficiency and pulmonary hypertension. EMBO Molecular Medicine, 2015.
Herr KJ, Tsang YN, En JO, Qiushi L, Yap LL Yu W, Yin H, Bogorad R, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Kotelianky V, Viasnoff V. Alpha-catenin elicits a cholestatic response and impairs liver regeneration. Scientific Reports, 2014.
Khan OF, Zaia E, Yin H, Bororad R, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG. Chemically modified dendrimers with alkyl chain-substituted amines for siRNA delivery to the liver endothelium in vivo. Angewandte Chemie, 2014.
Dahlman JE, Kauffman K, Langer R, Anderson DG. Nanotechnology for in vivo targeted siRNA Delivery. Advances in Genetics, 2014.
Platt RJ, Chen S, Zhou Y, Yim M, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovico M, Jhunjhunwala S, Graham DB, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Zhang F. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell, 2014. Featured on cover, and covered by Broad News.
Xue W*, Dahlman JE*, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. Small RNA combination therapy for lung cancer. PNAS, 2014, 111: E3553-E3561. Covered by MIT News.
Dahlman JE. A lesson in communication. Nature Nanotechnology, 2014, 9: 656.
Dahlman JE*, Barnes C* et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature Nanotechnology, 2014. Featured on cover. Highlighted in Nature Materials, MIT News, MIT Technology Review.
Dahlman JE, Langer R, Goldberg M. Lipid-like delivery materials for efficient siRNA delivery. Nanotechnology for the delivery of therapeutic nucleic acids. 2013.
Schroeder A*, Heller DA*, Winslow MM*, Dahlman JE*, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer, 2012.
Schroeder A*, Dahlman JE*, Sahay G, Love KT, Jiang S, Eltouhky AA, Levins CG, Wang Y, Anderson DG. Alkane-modified short polyethyleneimine for siRNA delivery. Journal of Controlled Release, 2012.
Whitehead K, Dahlman JE, Langer R, Anderson DG. Silencing or stimulation? siRNA delivery and the immune system. Annual Reviews of Chemical and Biomolecular Engineering, 2011.
Miracle DB, Wilks G, Dahlman A, Dahlman JE. The strength of chemical bonds in solids and liquids. Acta Materialia, 2011.
Dahlman J, Senkov ON, Scott JM, Miracle DB. Corrosion Properties of Ca based bulk metallic glasses. Materials Transactions, 2007.
Sago CD*, Lokugamage MP*, Lando GN, Djeddar N, Shan NN, Syed C, Bryksin AV, Dahlman JE. Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo. Nano Letters, 2018.
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco, CM, Shah NN, Castro MG, Anderson SE, Rudoltz TG, Lando GN, Tiwari P, Kirschman JL, Willett N, Jang Y, Santangelo PJ, Bryksin AV, Dahlman JE. A high throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. PNAS, 2018 (accepted).
Sago CD, Kalathoor S, Fitzgerald JP, Lando, GN, Djeddar N, Bryksin AV, Dahlman JE. Barcoding chemical modifications into nucleic acids improves drug stability in vivo. Journal of Materials Chemistry B, 2018. Invited - Emerging Investigators Issues.
Lokugamage MP, Sago CD, Dahlman JE. Testing thousands of nanoparticles in vivo using DNA barcodes. Current Opinion in Biomedical Engineering, 2018.
Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Castro MG, Bryksin AV, Dahlman JE. Analyzing 2,000 in vivo drug delivery data points reveals cholesterol structure impacts nanoparticle delivery. ACS Nano, 2018.
Paunovska K*, Sago CD*, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation. Nano Letters, 2018.
Budatha M, Zhang J, Yun S, Dahlman JE, Anderson DG, Schwartz MA. Inhibiting integrin alpha5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis. Journal of the American Heart Association, 2018.
Dahlman JE^^, Kauffman KJ*, Xing Y*, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET. Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. PNAS 2017.
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz M. Interaction between integrin alpha5 and PDE4D regulates endothelial inflammatory signalling. Nature Cell Biology, 2016.
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure. Circulation Research, 2016.
Sager HB*, Dutta P*, Dahlman JE*, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkjewicz GR, Iwamoto Y, Sebas Y, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Nanoparticle-enabled RNAi in endothelial cells reduces vascular inflammation after myocardial infarction. Science Translational Medicine, 2016. Featured on cover, covered by MGH news, and covered by Science.
Tibbitt MW, Dahlman JE, Langer R. Emerging frontiers in drug delivery. Journal of the American Chemical Society, 2016.
Dahlman JE^^, Abudayyeh OA*, Joung J, Gootenberg JS, Zhang F, Konermann S. Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease. Nature Biotechnology, 2015.
Stewart MP, Lorenz A, Dahlman JE, and Sahay G. Challenges in carrier mediated intracellular delivery: moving beyond endosomal barriers. WIRES Nanomedicine and Nanobiotechnology, 2015.
Koga J*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch ligand Delta-like 4 promotes the lesion development of vein grafts: implications for the treatment of vein graft failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 2015, 35: 2343-2353. Awarded best ATVB cover, 2015.
Khan OF, Zaia E, Jhunjhunwala S, Xue W, Wenxin C, Dong YS, Barnes C, Dahlman JE, Dong Y, Pelet J, Webber M, Tsosie J, Jacks T, Langer R, Anderson DG. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Letters 2015.
White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BR, Kumar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the miR-210-ISCU1/2 axis promote iron-sulfate deficiency and pulmonary hypertension. EMBO Molecular Medicine, 2015.
Herr KJ, Tsang YN, En JO, Qiushi L, Yap LL Yu W, Yin H, Bogorad R, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Kotelianky V, Viasnoff V. Alpha-catenin elicits a cholestatic response and impairs liver regeneration. Scientific Reports, 2014.
Khan OF, Zaia E, Yin H, Bororad R, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG. Chemically modified dendrimers with alkyl chain-substituted amines for siRNA delivery to the liver endothelium in vivo. Angewandte Chemie, 2014.
Dahlman JE, Kauffman K, Langer R, Anderson DG. Nanotechnology for in vivo targeted siRNA Delivery. Advances in Genetics, 2014.
Platt RJ, Chen S, Zhou Y, Yim M, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovico M, Jhunjhunwala S, Graham DB, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Zhang F. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell, 2014. Featured on cover, and covered by Broad News.
Xue W*, Dahlman JE*, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. Small RNA combination therapy for lung cancer. PNAS, 2014, 111: E3553-E3561. Covered by MIT News.
Dahlman JE. A lesson in communication. Nature Nanotechnology, 2014, 9: 656.
Dahlman JE*, Barnes C* et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature Nanotechnology, 2014. Featured on cover. Highlighted in Nature Materials, MIT News, MIT Technology Review.
Dahlman JE, Langer R, Goldberg M. Lipid-like delivery materials for efficient siRNA delivery. Nanotechnology for the delivery of therapeutic nucleic acids. 2013.
Schroeder A*, Heller DA*, Winslow MM*, Dahlman JE*, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer, 2012.
Schroeder A*, Dahlman JE*, Sahay G, Love KT, Jiang S, Eltouhky AA, Levins CG, Wang Y, Anderson DG. Alkane-modified short polyethyleneimine for siRNA delivery. Journal of Controlled Release, 2012.
Whitehead K, Dahlman JE, Langer R, Anderson DG. Silencing or stimulation? siRNA delivery and the immune system. Annual Reviews of Chemical and Biomolecular Engineering, 2011.
Miracle DB, Wilks G, Dahlman A, Dahlman JE. The strength of chemical bonds in solids and liquids. Acta Materialia, 2011.
Dahlman J, Senkov ON, Scott JM, Miracle DB. Corrosion Properties of Ca based bulk metallic glasses. Materials Transactions, 2007.